What Cambridge researchers say about British patient zero: “Other types may already be in circulation in the world”

Virus samples are coming to Sankar Company across the UK. The positive ones are combined and analyzed for mutations in large sequences. After 15 hours the genetic data is stored on the server farms. The analysis process takes a total of about five days. This lab alone processes about 10,000 samples per week – a quarter of the global order.

Evan Harrison, a microbiologist at the UK’s Genomics Integration Network, explains that their purpose is to identify mutations that can be highly contagious or cause severe disease and that could affect the safety of available vaccines.

The deployment of a large number of samples may reveal the pattern of circulation in the community and the location of the eruptions – a key role in these genetic analyzes, the researcher says.

Harrison is part of the UK Association of Genomics – a network of university research centers and laboratories to interpret the genetic data of the virus.

How the British version was invented

The British strain was identified by the network of these specialists and the number of genetic data collected by the health departments that examined the patients. A new strain was discovered in Kent in November – one of the poorest communities in the southeast of England.

Public health services say residents do not have to be part of the party and go to the same supermarket. However, the number of infections increased here and decreased due to locking everywhere.

At the time, one in 10 virus samples from across the country were deployed – enough to find the culprit for these social exchanges.

The mutant variant, P.1.1.7, has been spreading in the Kent since at least September, the researchers found. Following that, studies show that it is 30 to 70% contagious.

It spread rapidly to London and then to other parts of the UK. It has now been found in at least 70 countries, including the United States, which could dominate by March, U.S. health officials said.

Ravi Gupta, a professor at the University of Cambridge who studies the genetic line of the virus in his laboratory, says the second relative to the original strain in Wuhan, China is B1.1.7. Their genetic variation is given by 23 mutations, but the strange thing is that there are some close relatives to this British variant.

“I found very few – practically no footage closely related to the B1.1.7 variant. In other words, it is nowhere to be found,” Gupta explained.

British strain patient zero

Although the zero patient for this mutation is not always likely to be detected, British researchers have a theory.

Gupta examined the case of an uncompromising immune system patient infected with the virus for 3 months last year. He assumed that the virus had acquired mutations in this patient’s body, and that its immune system could not fight the virus faster – than if the virus had spread to others.

The patient did not survive. Gupta compared virus samples from this patient with viral variants from the genetic database – he had one of the mutations identified in the new strain, p.1.1.7.

Although the patient was not affected by this mutation, the researcher said that the patient with zero mutations in his samples may have been a person with an uncompromising immune system.

Harrison thinks so too.

Gupta’s laboratory research on the Pfizer / Bioendech vaccine shows that the serum works against the British version after a single dose – but its effectiveness is declining in people over 80 years of age. Studies on these vaccines have had similar results.

Pharmaceutical companies Pfizer and Moderna consider serum changes to be effective and against newer types.

The British strain already has mutations common to the South African strain – the UK public health services have already detected one of these mutations in a limited number of samples. Preliminary tests This is called “escape mutation” in the surface spike protein (the virus enters the cells) which allows the virus to produce pseudo-antibodies produced by the vaccine.

“These viruses are already evolving in the immune system and resistant to vaccines,” he said.

Mutations in spike protein may explain why these variants are more contagious than others.

But the virus needs a genetic sequence to adapt to vaccines. Sneger and 16 small laboratories in the UK account for more than half of the genetic testing carried out worldwide.

Public Health Services spokesman Ruirth Willer in the UK warned that only British, South African and Brazilian species could be identified, and that only these countries had the ability to deploy the virus, or other countries could not have done so.

“There may be others,” he says.

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