In a randomized controlled clinical trial, all volunteers were between 50 and 72 years of age and underwent a targeted diet for DNA methylation modification.
Biological aging is an umbrella term used to describe the cumulative effect of damage and loss of function on our cells, tissues, and organs. The DNAmAge Horvath watch is the gold standard for epigenetics research and predicts all-cause mortality and multiple morbidities better than chronological age.
Aging is a major factor in chronic disease, including cancer, neurodegeneration, type 2 diabetes, and cardiovascular disease, so the researchers wanted to test the effectiveness of the diet and lifestyle modifications in terms of balancing DNA methylation, and thus slowing or regressing. , Biological clock.
The researchers found that an immediate and profound decrease in the biological lifespan of the volunteers was indeed possible.
The diet included an unspecified diet of lean meat, fish and vegetables, but was mostly vegetarian. Intake of nutrient-dense animal protein, such as liver and eggs, was limited, as was carbohydrate intake. The volunteers also adhered to the program of moderate intermittent fasting. “To lower the glycemic cycle.”
Additionally, the participants received high doses of nutrients such as folate and betaine as well as vitamins C and A, and supplemented their diet with fruit and vegetable powder and a high dose (40 million CFU) of the probiotic, Lactobacillus plantarum 299v. L. plantar.
In addition to their dietary interventions, participants also participated in a minimum of 30 minutes of exercise per day, five days per week, to the intensity of 60 to 80% of their maximum perceived effort.
They also performed breathing exercises twice a day to reduce stress and received strict instructions to sleep at least seven hours each night.
Just eight weeks after the intervention, the study, conducted by the Helfgott Research Institute, found a three-year reduction in biological life compared to controls.
«… [It] Unique in its use for a safe, non-pharmacological diet and lifestyle, a control range, and a range of age reduction. We are currently recruiting participants to conduct a larger study that we hope will support these results. “ Says lead author Kara Fitzgerald.
The authors claim that delaying aging by 2.2 years could save $ 7 trillion over fifty years.
“This study provides the first insight into the potential for using natural modifications to target epigenetic processes and improve our well-being and possibly even longevity and longevity.” Said co-author and epigenetic geneticist Moshe Szyf.
In their findings, the authors recognize the limitations of their research and advocate “larger study groups and populations beyond middle-aged men.”
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