Should we look differently to find a cure?

Alzheimer’s diseaseIt is the most common form of dementia and affects more than 50 million people worldwide. According to researchers from Krumble Brain Institute Toronto,” A new patient is diagnosed every three seconds “.

However, despite hundreds of clinical trials conducted over the past 30 years, there are none There is no cure preventive or curative.

So we need to think differently about disease “Launching researchers.” So far, most approaches have been based on the theory that a protein called beta-amyloid, thought to be abnormal in the brain, clumps together. And when they clump together, they kill brain cells. In fact, we think beta-amyloid is actually exactly where it should be. It acts as an immune peptide – a messenger within our immune system – so if we have a head injury, beta-amyloid fixes it. If a virus or bacteria arrives, beta-amyloid is there to fight it. »

Function to be confirmed…

For scientists, Alzheimer’s disease occurs when beta-amyloid confuses bacteria and a brain cell. Then it inadvertently attacks our brain cells. In short, it could be an autoimmune disease.

Remember that an autoimmune disease results from a defect in the immune system that causes it to turn on the body and attack its natural components. This calls into question the idea of ​​the “amyloid cascade” coined in the early 1990s, according to which the accumulation of beta-amyloid in the brain leads to neuronal toxicity.

As you understand, before moving forward, this work very much needs confirmation. But for Dr. Donald Weaver, the author of this hypothesis, ” Concretely rethinking Alzheimer’s disease as an autoimmune disease and beta-amyloid as a natural part of our immune system will open the door to new avenues and new approaches to developing innovative treatments.. »

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Source: Alzheimer’s disease and dementia.

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