Autopsies again showed that SARS-CoV-2 can multiply in multiple organs, sites and body fluids in the case of a severe form of the disease. Including the brain. But the lungs remain the only organs whose tissues are truly affected.
related epidemic SARS-CoV-2 coronavirus It started exactly three years ago. Understanding of how they work is progressing bit by bit. Recent autopsies, his results published in December 2022 in naturereveal more about the spread of the virus in the human body.
These autopsies show how the SARS-CoV-2 coronavirus appears to have a tendency to persist cellularly in different parts of the body. A total of 44 autopsies were analysed, during which the scientists looked for and quantified the level of SARS-CoV-2 messenger RNA at 85 sites and body fluids. If a virus mRNA is detected, it means the virus has replicated there during the patient’s life — and quantification can gauge the extent.
Of the 85 sites and fluids analyzed, the researchers detected abundances of 79 coronavirus mRNA. For the patient profile, this is for unvaccinated older adults who died of a severe form of the COVID-19 disease.
SARS-CoV-2 is widespread.
Autopsies show that the infection can become ‘systemic’, that is, spread to multiple organs. Then the virus persists in the body for several months. This is not the first time involving risks systemic infection We are Shown by autopsyAnd this seems to be certain.
” We show that SARS-CoV-2 circulates widely, primarily in patients who have died of severe COVID-19, and that viral replication is present in many respiratory and non-respiratory tissues, including the brain, early in life. infection “, explain the authors. In total, the virus’s RNA has been identified in large quantities in the lungs, heart, kidneys, liver, some muscles, nerves, reproductive system, spleen, eyes or even the brain.
However, as a mostly respiratory virus, it is not surprising that the lungs show the most damage and inflammation. Other parts of the body affected by the multiplication of the virus, such as the brain or kidneys, are affected less or not at all by damage to their tissues, in physical terms.
This type of work offers additional keys to improving follow-up of patients with severe forms of the disease. Nothing butin FranceAs of early January 2023, another 1,300 people are in critical care.
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