- Farnesol is thought to prevent the loss of dopaminergic neurons, one of the main causes of Parkinson’s disease.
- Farnesol is also used in flavorings and in perfumery.
- The molecule will disrupt the activity of PARIS, a key protein involved in the development of Parkinson’s disease.
Eating fruit is always a good healthy idea. US researchers from Johns Hopkins University claim that one of the natural compounds, farnesol, which is also found in thrush and neroli, would prevent and reverse Parkinson’s disease brain damage. They present their findings in a study published July 28 in the journal Translational Medicine Sciences.
One of the main causes of Parkinson’s disease is the loss of dopaminergic neurons. Farnesol, which is also used in flavors and in perfumery, is said to prevent this phenomenon by disrupting paris, a key protein involved in disease progression. The loss of these neurons affects movement and cognition, resulting in characteristic Parkinson’s symptoms such as tremors, muscle stiffness, confusion, and dementia.
According to the researchers, farnesol’s ability to block paresis could guide the development of new interventions against Parkinson’s disease that specifically target this protein. “Our experiments showed that farnesol significantly prevented dopaminergic neuron loss and reversible behavioral deficits in mice, indicating its promise as a potential pharmacotherapy for the prevention of Parkinson’s disease.Said Ted Dawson, lead author of the study.
Protect the brain from the accumulation of paris
Dans le détail, dans le cerveau des personnes atteintes de Parkinson, une accumulation de protéines Paris ralentit la fabrication d’une protéine protectrice PGC-1alpha qui protège les cellules du cerveau des dommages causés par les’ molégécules ne cumulative ne ‘active molégésré ne the brain. Without PGC-1alpha, dopaminergic neurons die, leading to the cognitive and physical changes associated with Parkinson’s disease.
To study whether farnesol could protect the brain from the effects of the buildup of paris, researchers fed mice either a diet supplemented with this molecule or a regular diet for a week. Next, the researchers administered preformed fibrils of the protein alpha-synuclein associated with the effects of Parkinson’s disease in the brain.
Twice the number of healthy dopaminergic neurons
The researchers found that mice fed the farnesol diet performed better on a strength and coordination test designed to detect changes in Parkinson’s symptoms. On average, the mice performed better than the mice injected with alpha-synuclein, but fed a normal diet. When the researchers then looked at the brain tissue of mice in both groups, they found that mice fed a diet rich in farnesol had twice the number of healthy dopaminergic neurons. They also had about 55% more protective PGC-1alpha protein in their brains compared to untreated mice.
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